Further, injections of CRF and urocortin-1 into the basolateral amygdala reduces social interactions and thus indicating an anxiety-like behavior (Rainnie et al., 2004; Spiga et al., 2006), and the CRF-R1 specific antagonist NBI3b1996 injected into the basolateral nucleus of the amygdala attenuates the anxiety-like behavior (Gehlert et al., 2005). This evidence concerns the gene CRHR1 and Anxiety.