For instance, in male rats going through the maternal separation and then re-socialization, the anxiety-like behavior is reduced by injection of a general CRF antagonist (D-Phe-CRF(12−41)) into the dorsal raphe nucleus (Lukkes et al., 2009a) and the CRF-R2 expression is up-regulated in the dorsal raphe nucleus (Lukkes et al., 2009b). Here, CRHR2 is linked to Anxiety.