CRHR2 and Anxiety: The CRF-R1 have been reported to mediate the activation of the HPA/HPI axis (Timpl et al., 1998; Bale et al., 2002b; Huising et al., 2004) and to induce anxiety-like behavior (Britton et al., 1986; Heinrichs et al., 1997; Bale et al., 2002b), whereas the CRF-R2 have been reported to affect several other behavioral and physiological responses to stress (Liebsch et al., 1999; Coste et al., 2000; Bale et al., 2002b), and also to be involved in anxiety control (Bale et al., 2000, 2002a).