HMGA2 and glioblastoma: We observed increased SNAI1 expression in GBM cell lines after forced expression of LIN28A. The corresponding decrease in expression of let-7b and let-7g after LIN28A expression suggests that increased LIN28A suppresses let-7 microRNAs and de-represses HMGA2, which is then able to activate a program of increased pro-invasion genes, such as SNAI1. However, it is likely that LIN28A, as a master regulator of multiple microRNAs and downstream genes, can drive GBM tumorigenesis through a variety of mechanisms [15].