We infected cortex-derived human neural stem cells (hNSC) with lentiviruses encoding LIN28A together with dominant negative R248WTP53, constitutively active KRAS (CA-KRAS) and hTERT (hereafter referred to as hNSC- LIN28A/DNp53/hTERT/KRAS), all of which are known to be oncogenic elements in GBM [31-33]. This evidence concerns the gene KRAS and glioblastoma.