Specifically, knockdown of mtp53 was reported to induce the expression of GADD45, PTEN and PERP mRNA in a hepatoma cell line HUH-7, GADD45 and p21 mRNA in a breast cancer cell line T47D, and p21 mRNA in a nasopharyngeal carcinoma cell line CNE-2 [40]. The gene discussed is GADD45A; the disease is hepatocellular carcinoma.