Vil-Cre;BrafLSL-V637E/+ mice with heterozygous or homozygous mutation of p16Ink4a(Vil-Cre;BrafLSL-V637E/+;p16Ink4a∗) were aged and sacrificed at different time points to assess tumor incidence and latency (Figure 4B). The gene discussed is CDKN2A; the disease is neoplasm.