In a subset of mice (n = 5) dysplasia progressed to invasive carcinomas: 8.3% (1/12) of Vil-Cre;BrafLSL-V637E/+ mice younger than 10 months and 13.8% (4/29) of mice older 10 months had cancers (Figure 2A). This evidence concerns the gene VIL1 and invasive carcinoma.