BRAF and cancer: After the first reports of BRAF mutations in colorectal malignancy (Davies et al., 2002; Rajagopalan et al., 2002), it has soon been recognized that BRAF alterations are strongly associated with right-sided sessile cancers and its serrated precursor lesions HPs and serrated adenomas (Chan et al., 2003; Yang et al., 2004; Kambara et al., 2004; Spring et al., 2006).