We found that expression of TSP-1, TGF-β1, and NF-κB in patients with HBV hepatic fibrosis were all significantly higher than that in the serum of HBV carriers, suggesting that TSP-1, TGF-β1, and NF-κB play important roles in the process of hepatic fibrosis. The gene discussed is NFKB1; the disease is Hepatic fibrosis.