In the current study, we observed a decrease in methylation level at IGF2 DMR in cord blood cells of infants from preeclamptic women compared with those born to normally pregnant women, implying that hypoperfusion to fetal-placental unit occurs in very early life of embryonic development and that decreased methylation at IGF2 MDR is among the mechanisms linking exposure to maternal preeclampsia and health problems of late life. The gene discussed is IGF2; the disease is preeclampsia.