Our findings indicated that IGF-2 is one of the mechanisms involved in regulating fetal growth but this regulation was perturbed in preeclampsia and that preeclampsia-induced decrease in fetal DNA methylation at IGF-2 DMR might be among the mechanisms associating maternal preeclampsia and metabolic disorders in late life of the offspring, however, the confounding effect of other factors could not be completely excluded. This evidence concerns the gene IGF2 and metabolic disease.