IGF2 and Other metabolic disease: Our findings indicated that IGF-2 is one of the mechanisms involved in regulating fetal growth but this regulation was perturbed in preeclampsia and that preeclampsia-induced decrease in fetal DNA methylation at IGF-2 DMR might be among the mechanisms associating maternal preeclampsia and metabolic disorders in late life of the offspring, however, the confounding effect of other factors could not be completely excluded.