To explore the relationship between small for gestational age (SGA), a proxy for intrauterine growth restriction, and DNA methylation levels of imprinted genes, Tobi et al. [18] determined DNA methylation levels at IGF2, GNAS and other imprinted genes in SGA infants born preterm (before 32 weeks of gestation) and compared with infants appropriate for gestational age (AGA) born preterm, and found no significant differences in DNA methylation levels at any imprinted genes detected between AGA infants and SGA infants. This evidence concerns the gene GNAS and fetal growth restriction.