IGF2 and metabolic disease: Heijmans et al. [19] first described the relevance of periconceptional exposure to under-nutrition and hypomethylation at IGF2 DMR by reporting that maternal exposure to famine during Dutch Winter Hunger of 1944–45 led to hypomethylation at IGF2 DMR in their offspring and proposed that hypomethylation at IGF2 DMR was one of the mechanisms linking low birth weight and high risk of diabetes, hypertension and other metabolic diseases.