PIK3CA and breast cancer: Since AZD5363 induces FoxO3a nuclear translocation in ER+/PIK3CA mutant breast cancer cells [15] and ER mRNA in LTED cells (Figure 2A), we examined whether knockdown of ER and/or FoxO3a affects AZD5363-induced transcription of IGF-IR, InsR, and IGF ligands.