Another clinical trial in acute MI patients (NCT00126100: Bone marrow stem cell mobilization therapy for acute myocardial infarction [REVIVAL-2]), which was completed, reported that transplantation of blood-derived or BM-derived progenitor cells can improve cardiac regeneration and that G-CSF induces BM stem cell mobilization and increases the number of circulating stem cells available for this purpose [135, 136]. This evidence concerns the gene CSF3 and acute myocardial infarction.