According to the analysis of KEGG signaling pathway and the characteristics of GO in genome 18, some downregulated genes were found which are related to the tumor suppression pathway, such as BdnF mediated MAPK, Cflar, Cln3 Ddit3 Notch2 Rps6, Sox9, Spn, and Ppp1r13l. The gene discussed is SPN; the disease is neoplasm.