SERPINE1 and Insulin resistance: Adipocytes found in white adipose tissue exhibit altered physiology due to excess fat storage and release numerous pro-inflammatory cytokines and chemokines including TNF-α, IL-6, leptin, resistin, visfatin, adiponectin, monocyte chemotactic protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1), which serve to recruit additional immune cells and promote infiltration of macrophages, leading to a strong inflammatory cycle and eventually to insulin resistance at local and systemic levels [3, 18, 27].