Finally, diazoxide has been tested in the triple transgenic mouse model of AD (3xTg-AD) that harbors three AD-related genetic loci: human PS1M146V, human APPswe, and human tauP301L [127], and 3xTgAD mice treated with 10 mg/kg/day diazoxide for 8 months exhibited improved performance in the Morris water maze test and decreased accumulation of Aβ oligomers and hyperphosphorylated Tau in the cerebral cortex and hippocampus [128]. The gene discussed is MAPT; the disease is Alzheimer disease.