KCNJ8 and Alzheimer disease: In a rat model of neurodegeneration and in postmortem samples of patients with AD, we also reported that activated microglia strongly expressed KATP channel SUR components [90] and that reactive microglia increase their expression of the KATP channel components Kir6.1, Kir6.2, SUR1, and SUR2B after brain insults [92, 122].