Secondly, p53 accumulation in the form of aggregates has been observed in the perinuclear region of several tumor cell lines expressing endogenous p53 mutants, including MOG-G-CCM astrocytoma, HT-1376 bladder carcinoma, Detroit 562 pharynx carcinoma and 1301 T-cell leukemia [13]. This evidence concerns the gene TP53 and cerebral cavernous malformation.