On the other hand, previously reported disease-associated CNVs were detected using this approach (Table 5 and Figure S9) like, for example, well-known deletions spanning IRGM, LCE3 and ARMS2 loci, which have been respectively associated to Crohn's disease [37], psoriasis [36] and age-related macular degeneration [40]. The gene discussed is IRGM; the disease is age-related macular degeneration.