ERBB2 and breast cancer: Claudin 1 downregulation seems more prominent in ER+ [8,14] or ER+/HER2+ luminal [7,14] breast cancers, but is also a feature of some basal-like breast cancers including those belonging to the “claudin-low” subtype, which have low levels of claudin 1, 3, 4, 7 and 8 and poor prognosis [7,15].