In particular, the CX3CL1-CX3CR1 pathway is a key mediator of leukocyte chemotaxis and adhesion in human diseases such as atopic dermatitis [40], and in the animal models collagen-induced arthritis [41], experimental autoimmune myositis [42] and experimental autoimmune enecephalomyelitis [43]. This evidence concerns the gene CX3CR1 and atopic eczema.