CRP and familial Mediterranean fever: Notably, several additional clues argue for a role of heterozygosity in disease development: (i) many heterozygotes have mild elevation of acute phase reactants such as CRP or SAA [28]–[29]; (ii) heterozygous parents of FMF children have more inflammatory manifestations in their medical history than controls [30]; (iii) MEFV expression is increased and similar in patients carrying a single or two mutated allele(s) [16].