Concurrently with a 10–20 times increase in the relative expression of the pigMAP gene (ITIH4) a down-regulation of the pig AGP gene (ORM1) expression was seen in liver tissue 24 hours after experimental infection with two different serotypes of Actinobacillus pleuropneumoniae in separate experiments (serotype 2 and serotype 6), compared to a shared control group of six animals (Fig. 5A). The gene discussed is ITIH4; the disease is infection.