MAPT and Alzheimer disease: As shown in Figure 1, the biomarker profile using the Alzbio3 assay was consistent with prior studies showing decreased aβ42 (Mann Whitney U = 4.0, p < 0.0001, two-tailed), elevated levels of total tau (Mann Whitney U = 50, p = 0.0002, two-tailed) and increased phosphorylated (pT181) tau in the CSF of AD patients (Mann Whitney U = 97.5, p < 0.01, two-tailed) [28].