Our immunohistochemistry findings show that a/a ma ft/ma ft/J skin hosts significantly higher population of langerin positive cells, compared to WT mice (Fig. 2E and data not shown).These data suggest that barrier disruption in the a/a ma ft/ma ft/J mouse leads to a Th2-polarization and to increased number LCs, reminiscent of AD. Here, CD207 is linked to Alzheimer disease.