HJV and B-cell chronic lymphocytic leukemia: Regarding IGHV, DH and JH gene usage, no significant differences were found between the three groups of CLL-like B-cell clones, except for the VH3 and DH3 IGHV genes (Table 4): CLL showed lower frequency of VH3 usage and a greater proportion of DH3+clones vs MBLlo and MBLhi (P≤0.04) (Table 4).