The fact that these particular IGHV genes have been associated with previously reported stereotypic B-cell receptors in CLL clones [32], together with our own results which show that the complementary-determining regions (CDR3) of the IGHV genes are highly homologous in around one fifth of the B-cell clones from our short cohort (Table S3), would reinforce the role of some antigen-binding BCR specificities in clonal evolution. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.