BCR and B-cell chronic lymphocytic leukemia: In line with this hypothesis, IGHV genes over-represented among CLL clones (e.g.VH4-39 and VH1-69) frequently corresponded to IGHV genes enriched in genes encoding for antibodies that recognise a broad variety of relatively common and abundant (auto)antigens, including low-affinity BCR, e.g. myoglobulin, thyroglobulin, actin, and ssDNA [33], [34] associated with T-independent, type II autoimmune responses [35].