Taken together, these results would support the notion that antigen-driven BCR-stimulation could be a triggering factor in driving CLL-like B-cells to expand, in line with recent data showing a significant association between MBL in the general population and the individual history of infectious diseases and vaccination [39], whilst depending on the nature of the antigenic stimuli, distinct patterns of cytogenetic changes might then occur. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.