Such alterations include del(13q14), reported in around half of all CLL cases, trisomy 12, present in about one third of the patients and del(11q), del(17p), t(14q32) and NOTCH1 mutations, which occur in between 5-15% of all CLL cases [14], [23], [24]. The gene discussed is NOTCH1; the disease is B-cell chronic lymphocytic leukemia.