First, the cells treated with AZ12489875-002 were derived from SCLC tumors, while those treated with sEphB4-HSA or siRNA were derived from NSCLC tumors, and this may be the source of some fundamental differences in cellular biology among lung cancer subtypes, such as intrinsic differences between suspension cells (SCLC) versus adherent cells (NSCLC). This evidence concerns the gene ALB and non-small cell lung carcinoma.