In a pioneer study, genetic variant (rs3834129) in the CASP8 promoter region was associated with a wide range of solid cancers including lung, esophageal, gastric, colorectal, cervical, and breast cancers in Chinese populations by affecting the Sp1 transcriptional factor binding site and the CASP8 gene expression [14]. This evidence concerns the gene CASP8 and breast carcinoma.