As shown in Fig. 7, heat-treated eMOD could still reduce IgE-dependent basophil degranulation in response to Bet v1 (Fig. 7 A) and retained the ability to suppress allergen-induced airway eosinophilia (Fig. 7 B, C) and peribronchial and perivascular cellular infiltration and mucus production in lungs (Fig. 7 C). This evidence concerns the gene IGHE and Increased total eosinophil count.