These findings are in good agreement with result of antitumor effect (Figure 2), and are further supported by in vivo T cells or IFN-γ and TNF-αdepletion assay, showing that the loss of CD4+/CD8+ T cells or IFN-γ and TNF-αresulted in a significant increase in tumor volume compared with normal IgG-treated mice (Figure 7). Here, CD4 is linked to neoplasm.