[1] Therefore, it is vital for diabetic patients to recognize LLI and to control the risk factors of PAD as early as possible. It is well known that elder age, diabetes duration, cigarette smoking, poor glucose control, hypertension and hyperlipidemia are the traditional risk factors of arteriosclerosis for diabetic patients. [1] C-reactive protein (CRP), reflecting systemic inflammation, was one of the classical biomarkers for increasing risk of PAD. [2], [3] However, to our knowledge, the long-term predictive value of CRP for PAD was limited. The gene discussed is CRP; the disease is peripheral arterial disease.