There were significant differences in age, duration of diabetes, systolic blood pressure, GA, CRP, RBC, Hb, neutrophils, TP, albumin, BUN, Cr, cystatin C, GFR, TC, HDL-C, LDL-C, ALT, AKP, carotid and femoral IMT, prevalence of HTN, CAD and CI (all P<0.01) and HbA1c, AST, medication of aspirin and lipid lowering drugs (all P<0.05) between patients with and without LLI. This evidence concerns the gene GSTM1 and diabetes mellitus.