[26], [27] In a community-based, prospective study in elderly adults, the subjects with cystatin C higher than 1.27 mg/L had a 1.9-fold increased new onset of PAD events after semi-annually follow up. [11] However, there was no research to explore the association between cystatin C and the peripheral artery diseases of lower limbs in diabetic population so far. This evidence concerns the gene CST3 and peripheral arterial disease.