Thirty-six sequence variants, including 16 polymorphisms (7 novel polymorphisms: c.411C>A (p.Ser137Ser), c.2289C>T (p.Phe763Phe), c.2502C>G (p.Val834Val), c.3973C>T (p.Leu1325Leu), c.3999G>T (p.Leu1333Leu), IVS8+26A>G, and IVS8+27G>A), in the ATP7B gene were observed by screening 18 probands of our 18 Chinese Han families with WD [6] (Figure 1A). Here, ATP7B is linked to Wilson disease.