The periodontium of rats presenting with experimental periodontitis receiving no treatment (EPD) showed marked immune-staining for to the following markers: MMP-2, MMP-9, COX-2, RANK-L, and RANK (Figure 2B, E, H, K, and N) compared to periodontium staining profile of the saline group (Figure 2A, D, G, J, and M). Here, TNFSF11 is linked to periodontitis.