The primary outcome for study 1 [16] was the safety of rituximab, determined by adverse events (AEs) and serious AEs, including worsening MS, number and severity of infusion-associated events (defined as those reported during or within 24 hours of an infusion), number and severity of infectious AEs, any clinically significant changes in laboratory or vital sign measurements, the incidence of human anti-chimeric antibodies (HACA) and the total number of Gad-enhancing T1 lesions over the 72-week trial. The gene discussed is GAD1; the disease is myeloid sarcoma.