Exploratory outcomes included time to CDP sustained for ≥24 weeks, change in Multiple Sclerosis Functional Composite (MSFC) summary and component scale scores, CD19+ B-cells counts and immunoglobulin levels and pre-specified subgroup analysis by age, gender, race/ethnicity, use of prior therapy, EDSS at baseline, duration since MS symptom onset and presence of Gad-enhancing lesions on brain MRI at baseline. The gene discussed is CD19; the disease is multiple sclerosis.