While previous reports characterized the suppressive effect of CD11b+GR-1+ from cytokine-activated bone marrow and spleen [26], [31], [32], and the immunosuppressive activity of CD11b+ Ly6C+ Ly6G− mononuclear cells in the blood of non-tumor-bearing mice [33], and multiple hematopoietic tissues (BM, blood, spleen, and peripheral lymph nodes) of healthy aged mice [34], we studied IMCs purified from non-stimulated bone marrow by FACS. Here, ITGAM is linked to neoplasm.