To compare suppressive activity of CD11b+GR-1+ IMCs isolated from the BM of non-tumor bearing mice with BM and spleen-derived MDSCs from tumor-bearing animals, we sorted myeloid progenitors from tumor-bearing and non-tumor-bearing mice and determined their suppressive activity by titrating ratios of myeloid cells: T-cells and measuring T-cell proliferation in vitro. The gene discussed is ITGAM; the disease is neoplasm.