ERN1 and Insulin resistance: Recently, low grade inflammation and endoplasmic reticulum (ER) stress have been proposed to be in close association with insulin resistance, activation of inflammatory pathways, such as Jun N-terminal kinases (JNKs), inhibitor of nuclear factor B(IkB) kinaseβ (IKKβ), inositol requiring enzyme 1 (IRE-1), could coverage [21–23].