G6PC1 and type 2 diabetes mellitus: Although, previous in vitro studies have found that some Chinese herbs are able to decrease serum levels of glucose, glycosylated proteins, and hemoglobin A1C, possibly by blocking intestinal absorption and/or inhibiting hepatic glucose-6-phosphatase [50, 54], there have not yet been any clinical trials that have demonstrated the efficacy and safety of Liu-Wei-Di-Huang-Wan and its derivatives when treating diabetes type 2.