After 12 weeks of treatment, 8 weeks of washout, and finally the reversal of the treatments in the two groups, arterial pressure in metformin groups reduced to normal values, both in peripheral systolic and diastolic pressure and central systolic and diastolic pressure values, which demonstrated a close relationship between insulin resistance and a hypertensive condition in PCOS patients (23). Here, INS is linked to polycystic ovary syndrome.