Taking into account that visfatin/Nampt is expressed in periadventitial and apical epicardial adipose tissues [64], and with the recent evidence that it is also secreted by rat cardiomyocytes [94], not only circulating visfatin/Nampt but also visfatin/Nampt locally produced in the CV system could play a detrimental role in promoting myocardial fibrosis and remodeling. Here, NAMPT is linked to Myocardial fibrosis.