NLRP3 and obesity due to melanocortin 4 receptor deficiency: Ablation of the NLRP3 in mice has been also reported to protect from obesity-associated macrophage activation in adipose tissue, reducing M1-like macrophage gene expression (tumor necrosis factor-α, chemokine ligand 20, and chemokine ligand 11) and increasing the expression of M2-like cytokines (interleukin-10).