INS and Insulin resistance: In an animal study aimed to evaluate the renal consequences of the chronic administration of high-fructose corn syrup (HFCS-55), the major sweetener in foods and soft-drinks, we have recently demonstrated that HFCS-55 feeding caused a significant increase in body weight and more importantly dyslipidemia, hyperinsulinemia, and an increase in insulin resistance due to impaired insulin signaling [60].