TNF and myeloid sarcoma: In particular, adipose tissue-related production of proinflammatory molecules (TNF-α, IL-1β, IL-6, IL-8, transforming growth factor-β, and nerve growth factor) as well as its acute-phase response (plasminogen activator inhibitor-1, haptoglobin, and serum amyloid A) [45] detected during obesity contributes to a low grade of systemic inflammation seen in chronic diseases associated with MS [46–49].