Not surprisingly, the patient-derived NSCLC xenograft models, L121 & L123 with FGFR1 gene amplification were insensitive to gefitinib treatment (Table 3 and Figure 3), likely due to a tumor-dependence on FGFR pathway signaling [23,24]. The gene discussed is FGFR1; the disease is non-small cell lung carcinoma.