At M6, 13 (19%) HIV + TB- patients had virologic failure (HIV RNA >5000 copies/ml), for which baseline BMI < 18.5 kg/m2, CD4+ count < 100 cells/μl, and WHO stages 3 and 4 [OR: 3.8, 2.3, 4.9; p = 0.05, 0.32, 0.02, respectively] were risk factors. The gene discussed is CD4; the disease is tuberculosis.