Compared to IFN-γ response in LTBI individuals (HIV-TST+) (491.2 pg/ml) at baseline, there was significantly lower IFN-γ production in HIV + TB + (3.6 pg/ml) (p = 0.004), in HIV-TB + (34.4 pg/ml) (p = 0.004), and in HIV + TST + (46.3 pg/ml) patients (p = 0.002). This evidence concerns the gene IFNG and tuberculosis.