Various studies suggest Tumor Necrosis factor α(TNF α) [3], Transforming Growth Factor β(TGF β) [4], Vascular endothelial Growth Factor (VEGF) [5], Activin receptor like kinase (ALK) [6], Interleukins(ILs) [7], and Interferons(IFN) [8] regulate the bone marrow milieu in MDS. This evidence concerns the gene TNF and myelodysplastic syndrome.