Historically, older drugs have typically been tested in clinical trial participants with higher baseline HbA1c, so, without direct comparisons, it is difficult to be certain that SUs, for example, really are more or less effective that DPP-4 inhibitors or GLP-1 agonists; but these latter are consistently found not to be inferior to SUs, with the added benefit of no weight gain, even weight loss, without hypoglycemia [1,11-18]. The gene discussed is DPP4; the disease is Hypoglycemia.