Six targeted agents for the treatment of advanced RCC are now approved and in clinical use: the tyrosine kinase inhibitors sunitinib and pazopanib, the multikinase inhibitor sorafenib, the anti–vascular endothelial growth factor monoclonal antibody bevacizumab, and the mammalian target of rapamycin (mTOR) inhibitors temsirolimus and everolimus[1]. The gene discussed is MTOR; the disease is renal cell carcinoma.