In the only placebo-controlled study, 1.8 g/day of eicosapentaenoic acid for 3 months reduced CAVI in 92 subjects with the metabolic syndrome by 3.6% in conjunction with reducing serum concentrations of triglycerides, C-reactive protein and serum amyloid A in LDL, and an increased serum adiponectin level [28]. The gene discussed is ADIPOQ; the disease is metabolic syndrome.