UCP1 and obesity due to melanocortin 4 receptor deficiency: The role of UCP1 in the development of obesity and DM2 has been reviewed in 2010 and 2012 [14, 15]; the authors focused on the polymorphisms −3826A/G, −1766A/G, and −112A/C in the promoter region, Ala64Thr in exon 2, and Met299Leu in exon 5 of UCP1 gene and pointed out that they are possibly associated with obesity, lipid/lipoprotein-related disease, and/or DM2.