GP6 and diabetes mellitus: In conclusion, we have demonstrated exacerbated platelet intracellular ROS and calcium flux associated with engagement of GPVI in monkeys with poorly controlled diabetes and that inhibition of a specific signalling protein (Syk) reduced GPVI-dependent ROS generation regardless of the level of glycaemic control in diabetic monkeys, indicating that Syk inhibition could prove to be an effective antiplatelet strategy for diabetic patients.