In conclusion, we have demonstrated exacerbated platelet intracellular ROS and calcium flux associated with engagement of GPVI in monkeys with poorly controlled diabetes and that inhibition of a specific signalling protein (Syk) reduced GPVI-dependent ROS generation regardless of the level of glycaemic control in diabetic monkeys, indicating that Syk inhibition could prove to be an effective antiplatelet strategy for diabetic patients. The gene discussed is SYK; the disease is diabetes mellitus.