CRP and Fabry disease: Notably, several clinical and laboratory findings, as the occurrence of episodic and unexplained fever in some patients with FD, and/or the increased serum levels of ESR, CRP, and α1- and α2-globulin (observed also in 45.8% of our patients with FD) indicate the likely occurrence of both systemic and local inflammation in this pathology [30, 31].