However, a number of patients with CML die due to ABL mutation-related drug resistance and blast crisis because IM does not kill leukemia stem cells (LSCs), which persist in a majority of patients and may cause disease relapse, and clinical resistance may develop predominantly due to point mutations in the ABL kinase domain [2]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.