To make the diagnosis of ALK-negative ALCL, there must be a large cell predominant population with abundant cytoplasm and pleomorphic, embryo or hallmark nuclei or wreath-like giant cells, and strong CD30 expression with a membrane and Golgi distribution in virtually every cell with a highly anaplastic T-cell phenotype [17, 19]. Here, TNFRSF8 is linked to anaplastic large cell lymphoma.