Significant similarities in expression direction and magnitude were detected when the gene expression pattern in Shn-2 KO medial PFC (mPFC) was compared with the pattern in schizophrenic frontal cortex (Brodmann area 10, BA10) examined postmortem [86]; 100 altered genes were detected in both Shn-2 KO mice and patients with schizophrenia. The gene discussed is HIVEP2; the disease is schizophrenia.