Resveratrol has also been shown to reduce neural inflammation in PD by lowering mRNA levels of cyclooxygenase-2 (COX-2) and TNF-α mRNA in the substantia nigra [100] along with attenuation of oxidative stress, lipid peroxidation, and protein carbonyl (PC) in rat model of PD [138]. This evidence concerns the gene TNF and Parkinson disease.