TP53 and hepatocellular carcinoma: In conclusion, we demonstrated that Fbxw7 can be activated by adenoviral delivery of p53, leading to increase proteasomal degradation of c-Myc and Cylin E. Low levels of the studied cell cycle regulators might attenuate the oncogenic phenotype of HCC cell lines by restricting G1-S transition and c-Myc mediated cell cycle reentry.