BHMT and hyperhomocysteinemia: Interestingly, the phenotype we observed here on the male offspring is somehow, but to a less extent, similar to the phenotype of the Bhmt (Betaine-homocysteine methyl transferase) knock-out mice model which is characterised by an increased energy expenditure, reduced weight gain and reduced adiposity despite a normal food intake, associated with an hyperhomocysteinemia [53].